Researchers have been able to reverse the age - related deprivation of functionality in enteral stem cells in a very unsubdivided way . A 24 - hour fasting has been shown to dramatically improve how these important cell regenerate in both old and untried mice .
The report , reported inCell Stem Cell , looked at the effect of dieting on the bowel cells of new and old mice . What the researchers discovered was that after just a single day of fast , the cells underwent a switch in behavior . They stopped burning carbohydrates and started burning fat . And once the electric cell jump burning fat acids their functionality got good .
“ enteric root cell are the workhorse of the intestine that give rise to more theme cells and to all of the various differentiated cell types of the intestine . Notably , during aging , intestinal stem mathematical function decline , which spoil the ability of the gut to repair itself after damage , ” elderly writer prof Omer Yilmaz , from MIT ’s Koch Institute for Integrative Cancer Research , said in astatement . “ In this line of probe , we concentre on understand how a 24 - hour immobile enhances the social function of young and quondam intestinal stem cell . ”
What the team realized is that once the mouse get fast , certaintranscription factors – proteins that help convert DNA to RNA – activated . They are name PPARs . When they are switched off the mobile phone ca n’t burn fatty acids , and the analysis point that when this hap the cell can no longer boost regeneration . The opposite is also true . The team aerate the PPARs while the mice were not fast and still got the good burden .
“ That was also very surprising , ” co - lead author Chia - Wei Cheng added . “ Just activating one metabolic nerve pathway is sufficient to reverse certain age phenotypes . ”
The finding are really crucial . The discovery that fast aid the intestine regenerate is important in its own right , but combine it with the potential of but using a drug to prevail the same effect makes this a central study for medical interventions on the lower digestive scheme . It could , for example , help patients recuperate from chemotherapy or gastrointestinal infections .
The squad is now rum to observe out whether cellphone in other part of the organic structure also have this capability . Fasting or the use of the drug could hike up tissue longevity in many unlike organs .
